Viral infections as potential triggers of type 1 diabetes
نویسندگان
چکیده
منابع مشابه
Viral Trigger for Type 1 Diabetes
The most popular hypothesis circulating within and beyond the scientific community is that viral infections enhance or elicit autoimmune disorders such as type 1 diabetes. Indeed, viruses can injure -cells and have been isolated in pancreatic tissues from diabetic patients. However, accumulating evidence suggests that the opposite scenario, which is prevention or amelioration of type 1 diabetes...
متن کاملEnvironmental triggers and determinants of type 1 diabetes.
Type 1 diabetes is perceived as a chronic immune-mediated disease with a subclinical prodromal period characterized by selective loss of insulin-producing beta-cells in the pancreatic islets in genetically susceptible subjects. A series of evidence supports a critical role of exogenous factors in the development of type 1 diabetes, such as 1) the fact that <10% of individuals with HLA-conferred...
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Susceptibility to autoimmune diseases is dictated by a complex interplay of genetic determinants and environmental factors. Viral infections have long been suspected to be involved in the etiology of several autoimmune disorders. In particular, the incidence of type 1 diabetes worldwide is increasing at a yearly rate that cannot be solely attributed to genetic changes in the population and envi...
متن کاملVirus infections in type 1 diabetes.
The precise etiology of type 1 diabetes (T1D) is still unknown, but viruses have long been suggested as a potential environmental trigger for the disease. However, despite decades of research, the body of evidence supporting a relationship between viral infections and initiation or acceleration of islet autoimmunity remains largely circumstantial. The most robust association with viruses and T1...
متن کاملImmunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice.
Type 1 diabetes (T1D) is an autoimmune disease that is caused by the destruction of insulin-producing beta cells. Viral infections induce immune responses that can damage beta cells and promote T1D or on the other hand prevent the development of the disease. However, the opposing roles of viral infections in T1D are not understood mechanistically. We report here that viruses that do not inflict...
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ژورنال
عنوان ژورنال: Diabetes/Metabolism Research and Reviews
سال: 2007
ISSN: 1520-7552,1520-7560
DOI: 10.1002/dmrr.695